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I think with Agito. Agito fooled him around while "working" for Cronos. Guyot even called him "my right hand man" in VIZ's translation. ----------------

Venom type Symbiotic beings would lose each time. Control metal regulates it, even if it didn't, the Guyver one is shown to be stronger in that it's not just a symbiote, but an organism that completely devours it's host in seconds. The symbiotes in marvel need time and don't have full control. SO a wild Guyver symbiote would be the biggest threat to Marvel and Cronos's worlds if you think about it. It can fuse with anyone and everything, and take their aiblities, and it can nearly be un-killable because of it's ability to split and regenerate. It's pretty much the THING from the "THE THING" horror movies minus intelligence. .