As far as combat ability 47 is very much outclassed by zoanoids considering that most modern day weapons simply lack the firepower to put down a mass production type zoanoid like Gregole who was able to take a point blank grenade blast and was more or less fine. He is also out gunned by bio blaster type zoanoids like Vamore or Gaster. Agent 47 and zoanoids have very different jobs, which is why comparing the two is almost unfair. while one is designed to take out high priorty targets without being caught the other is deigned to crush enemies with overwhelming force, mind you Cronos was able to conquer the entire planet in a single day with relative ease. Agent 47 does not have the combat ability to go toe to toe with most things in Guyver.