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Venom type Symbiotic beings would lose each time. Control metal regulates it, even if it didn't, the Guyver one is shown to be stronger in that it's not just a symbiote, but an organism that completely devours it's host in seconds. The symbiotes in marvel need time and don't have full control. SO a wild Guyver symbiote would be the biggest threat to Marvel and Cronos's worlds if you think about it. It can fuse with anyone and everything, and take their aiblities, and it can nearly be un-killable because of it's ability to split and regenerate. It's pretty much the THING from the "THE THING" horror movies minus intelligence. .

depression is the result of feeling powerless. Out of all the characters in Guyver, that is not Shou. Shou has the power to make a difference and as such, he is probably in a good mental state. He is beseiged in many ways and he probably has some anxiety about that, but mostly, he knows he can always take action. He has a mission and purpose. If anyone were depressed it would be Mizuki. I think this has been shown in the series as well.. I recall times when she has expressed a feeling of helplessness. The time when she went to look for her parents, very indicative of desperation and depression.